Refractory epilepsy: treatment with new antiepileptic drugs
نویسندگان
چکیده
منابع مشابه
Refractory epilepsy: treatment with new antiepileptic drugs
Five antiepileptic drugs have been marketed in the last decade. We report here a retrospective study of patients attending our unit who were prescribed one of the new antiepileptic drugs. All these patients had refractory localization related epilepsy and had failed to respond to a first-line drug. The drugs had a different profile of side-effects but topiramate (42%) was the most common drug t...
متن کاملExperience with new antiepileptic drugs among Indians with refractory epilepsy
Objectives: We assessed the comparative efficacy and tolerability of topiramate (TPM), lamotrigine (LTG), gabapentin (GBP) and clobazam (CLB) with an aim to formulate clinical guidelines while initiating treatment with new anti-epileptic drugs (AEDs). Methods: A prospective open label, nonrandomized, add-on study was conducted on 203 Indian patients with seizures refractory to conventional AEDs...
متن کاملEfficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy
Objective: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee including general neurologists, pediatric neurologists, ...
متن کاملAntiepileptic Drugs and Mental Health Status of Patients with Epilepsy
Many patients with epilepsy suffer also from coexisting psychological problems. These mental co-morbidities have a significant impact on quality of life of patients with epilepsy. Recent studies have shown that although antiepileptic drugs (AEDs) treat epilepsy, they may increase risk of mental disorders in these patients . Due to the lack of adequate research in this area, we assess...
متن کاملTopiramate: a new antiepileptic drug for refractory epilepsy
Topiramate is a recently licensed and marketed antiepileptic drug in the UK for use as add-on therapy for refractory partial epilepsy. It has multiple modes of action involving voltage-dependent sodium channels, GABA receptors and glutamate receptors. Topiramate has very favourable pharmacokinetics as it is primarily excreted unchanged. Its metabolism is, however, increased by enzyme inducers, ...
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ژورنال
عنوان ژورنال: Seizure
سال: 2000
ISSN: 1059-1311
DOI: 10.1053/seiz.1999.0348